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Consciousness, Cognition and the Neuronal Cytoskeleton – A New Paradigm Needed in Neuroscience
Viewing the brain as a complex computer of simple neurons is insufficient to explain consciousness and cognition. A new paradigm is needed that considers the brain as a scale-invariant hierarchy, with quantum and classical processes occurring in cytoskeletal microtubules inside neurons. Evidence shows that microtubules regulate specific firings of axonal branches and modulate membrane and synaptic activities. This new paradigm suggests that information processing for cognitive and conscious brain functions occurs in microtubules and involves both top-down and bottom-up regulation within the brain hierarchy. The precise mechanisms of consciousness may be most likely to reveal themselves in Layer V cortical pyramidal neurons, which have a large collection of mixed polarity microtubule networks.
OpenMEA: Open-Source Microelectrode Array Platform for Bioelectronic Interfacing
OpenMEA is an open-source platform for closed-loop bioelectronics research that aims to revolutionize the treatment of medical disorders and augment physiology. It includes designs for components such as electrophysiological recording and stimulation electronics, a microfluidic perfusion system, and physical designs for multielectrode arrays. The platform enables researchers to conduct in vitro experiments and understand the long-term effects of electrical stimulation and drug interactions. OpenMEA offers high-performance processing capabilities and supports simultaneous recording and stimulation, as well as the real-time adaptation of neuromodulation waveforms. It fills the gaps in existing solutions and provides a versatile tool for bioelectronic research.
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